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(2015) described a vicious cycle in which impairment of the surface barrier allows the penetration of allergens, which causes chronic inflammation, disturbed KC differentiation, and altered tight junction formation with further disruption of the barrier
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To survive and proliferate in this condition, PAAD cells trigger a series of specific metabolic pathways to meet their huge energetic and biomass demands, such as enhanced glucose and glutamine metabolism, which are driven by the KRAS oncogene [79]
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