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Indeed, in human THP1 differentiated macrophage-like cells (THP1 MΦ) and in mouse primary bone marrow-derived (BM)MΦ, a 2-h treatment with the synthetic GC dexamethasone induced expression of the canonical GR target Fkbp5 as well as genes with known anti-inflammatory function: SGK1 , PER1, DUSP1, KLF9 , A20 , GILZ , IL10 and Sgk1 , Per1 , Dusp1, Klf9, Ccl17 and Gilz in human and mouse, respectively 7,25,26,27,28,29,30 (Supplementary Fig

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Xenografted colorectal cancer cells overexpressing B7-H3 were more resistant to oxaliplatin while treatment with 2-Deoxy-D-glucose (2-DG), an HK2 inhibitor, reduced tumor size and tumor regrowth rate