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While it was shown that GDF8 and GDF11 signal through similar receptors, a direct rigorous comparison of the ligands had not been performed until we published a study demonstrating that GDF8 and GDF11 have significant differences in their signaling properties in multiple cell lines, showing that GDF11 is much more potent than GDF8
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"Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta4, in equine urine and plasma by liquid chromatography-mass spectrometry." J Chromatogr A
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