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Our results delineate that TMPRSS2-PAR2 signaling regulates postprandial GIP release in lean mice, but that this signaling axis is overlaid by additional functions of TMPRSS2 in the context of hypercaloric weight gain and the associated dysregulation of glucose homeostasis and insulin resistance
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Although ferroptosis can lead to neurodegenerative processes associated with mitochondrial dysfunction, mitophagy [8], autophagy, or ferritinophagy [9], and are implicated in hypoxic brain injury [10, 11], less than 100 articles link ferroptosis with epilepsy
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