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From the literature, it is therefore clear that the most important physiopathogenic events are the following: penile injury (including minor trauma), formation of blood collection in the corpus cavernosum, recruitment of inflammatory cells, release of ROS and cytokines, activation of transcription factor NF-kB, the production of iNOS and the subsequent overproduction of radical NO, and the overproduction and local deposition of collagen (plaque formation) (Figure 1)

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