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These findings are in alignment with later mechanistic studies that highlight the involvement of the miR-30b-5p/Notch axis (50)
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This suggests that stimulation of the α 1A -AR subtype, and not the α 1B -AR, can induce sustained ERK 1/2 activation upon phenylephrine treatment, and that phenylephrine-dependent α 1A -AR internalization occurs via a concanavalin A-sensitive mechanism (Perez-Aso et al., 2013)
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