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During the early stages of inflammation, melatonin functions transiently as a proinflammatory agent for 2–3 hours, which is necessary for adaptation to acute stress.35 However, in later stages, it suppresses inflammation by inhibiting the binding of NF-κB to DNA and downregulating Cyclooxygenase-2 (COX-2) expression.36 Similarly, intracellular GSH levels typically decrease during early inflammation, which can trigger NF-κB activation and promote the production of essential proinflammatory cytokines

كريم يقوي البشرة ضد العوامل البيئية

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10.1111/j.1365-2796.2011.02428.x 133

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