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Yang Tang, [email protected] †These authors have contributed equally to this work and shared first authorship This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The activation of Nrf2 leads to its binding to the ARE, this in turn results in the increased expression of antioxidant enzymes and detoxifying enzymes, consequently protecting normal cells from the toxic effects of chemotherapy while making cancer cells more susceptible to the drugs [92]