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Several mechanisms contribute to the uncoupling of eNOS, including deficiency of the cofactor tetrahydrobiopterin (BH4), depletion of the substrate L-arginine, and accumulation of asymmetric dimethylarginine (ADMA), a competitive inhibitor of eNOS [69]
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Funding Statement This work was supported by the National Research Foundation of South Korea (NRF) grant funded by the South Korea government (MEST) (No
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