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Unlike their mitochondrial homologs, cytosolic CGFS Grxs are multidomain proteins with a Trx-like domain at the N-terminus, usually with a modified monothiol active site (WAxxC), and one to three CGFS Grx domains in tandem at the C-terminus (Fig

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Recently, despite a lack of significant association between hyperhomocysteinemia and the risk of venous thromboembolism, in a prospective study of patients with systemic lupus erythematosus, Petri et al (1996) report that hyperhomocysteinemia, defined as total plasma homocysteine concentrations higher than 14.1 μmol/L, is significantly associated with arterial thrombotic events (odds ratio 3.74), and stroke (odds ratio 2.24)