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These findings establish ferroptosis as a major cell death mechanism in glutamatergic models of glaucoma, complementing the role of ferroptosis in pressure-induced RGC injury [35] . 6.8 p38 mitogen-activated protein kinase (MAPK) signaling The p38 MAPK pathway has emerged as a critical regulator of glutamate-induced ferroptosis in RGCs
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Human studies consistently report that doses up to 6 g are well tolerated, with no adverse effects noted even in older adults
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