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Rather than inducing desensitization, a chronic morphine treatment could promote a compensatory increase in intracellular cAMP level (also named cAMP overshoot or ACase superactivation) (Avidor-Reiss et al., 1995) and is believed to play a direct role in tolerance (Duman et al., 1988
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[DOI] [PMC free article] [PubMed] [Google Scholar] Pumford NR, Hinson JA, Benson RW, Roberts DW
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