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AEP is present in the endolysosome and is implicated in causing aberrant cleaving of amyloid precursor protein (APP N585) and tau N368 leading to plaques and neurofibrillary tangles (NFTs), while C/EBP-β is involved in inducing expression of proinflammatory signaling molecules in microglia and astrocytes and participating in a vicious feedback loop that worsens in an age-dependent manner (Wang et al., 2018)
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