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Two different mechanisms have been reported for the SOD action that restricts the transformation 1) It majorly acts at the cell membrane level and eliminate or prevent the generation of radical that can result from the peroxidation of lipid and leads to the chain of extra-nuclear and nuclear events, ultimately cause transformation

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In the absence of genetic defect in SSTR2, SSTR5, and DRD2 genes, alterations have been reported in molecules involved in the intracellular signal transduction pathway specific of these receptors, and in the regulation of receptors expression