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Overproduction of peroxynitrite contributes to increasing neuro-excitatory and pro-inflammatory cytokines (TNF-alpha and IL-1beta) and to decreasing anti-inflammatory cytokine (IL-10 and IL-4) production (Ledeboer et al., 2007
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Hydroxyl free radicals released by CIS are involved in the phosphorylation of p38 MAPK and the regulation of TNF-α synthesis, leading to the activation of NF-κB [ 58 ]
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