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As many of these medications have been identified as potential contributors to musculoskeletal pain in the orofacial region due to an impact on muscle physiology, pain modulation, electrolyte balance, sleep, or parafunctional activities, a careful review of a patient’s medication history deserves consideration whenever the clinical picture seems more complicated than expected

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However, large-scale, prospective studies are urgently needed to establish reproducibility, predictive validity, and regulatory acceptance of these biomarkers