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The N-terminal Pro-Pro-Pro (PPP) triplet at positions 3–5 forms a polyproline II helix , which is the structural basis for the peptide’s documented resistance to gastric proteolysis—BPC-157 remains structurally intact after in vitro incubation in gastric juice (pH 1–2, pepsin 0.5–1 mg/mL)

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1,6 Once stable, maintenance therapy can be decreased to an injection once every month or every other month