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S-glutathionylation in cancer: from fundamental mechanisms to clinical applications - ScienceDirect

Abstract All organisms have thioredoxin reductase (TR) or glutathione reductase (GR), the only enzymes that use reduced nicotinamide adenine dinucleotide phosphate to reduce cytosolic disulfides into thiols, thereby powering deoxyribonucleotide biosynthesis, elimination of oxidants, oxidative damage repair and reduction of the disulfide nutrient cystine into the thiol amino acid cysteine

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Outcome (mRS) was noted at discharge and 90 days follow up