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The Anti-Inflammatory and Immunomodulatory Activities of Natural Products to Control Autoimmune Inflammation - PMC

The Oxidative Stress Connection GGT's role in glutathione metabolism links it directly to oxidative stress, a key driver of insulin resistance: Increased oxidative stress disrupts insulin signaling pathways Elevated GGT reflects the body's attempts to manage this stress Progressive insulin resistance develops as protective mechanisms fail Metabolic syndrome emerges with multiple risk factors clustering together This progression explains why GGT often elevates years before fasting glucose or hemoglobin A1c show abnormalities

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Air Qual Atmos Health 4 , 79–93 (2011)